Immune cell based diagnosis

TECHNOLOGY


Convergence Technology: Biotechnology, nanotechnology and information technology were combined to develop our innovative POCT device and instrument.

• Nanotechnology: We develop the Nano filter technology for leucocyte separation. Which is unique and more reliable technology. Recovery rate of leuco-separation is more than 95%. We focus our objective to maximize the recovery rate more than 90%. After so many failure finally, we succeeded to achieve the maximum rate of leucocyte recovery.


• CMOS: The safe and reliable technology for POCT device which has more advantage than CCD technology.


• Photometry: Our technology involves the innovative method of photometry over traditional method of cytometry. This technique provides better platform for rapid screening of immune cells analysis.

HIV/AIDS


• HIV/AIDS stands for Human immunodeficiency virus infection and acquired immune deficiency syndrome.


• HIV target the body’s immune system, specifically the CD4 cells. If, the HIV remain untreated, it reduces the total count of CD4 cells (T Cells) in the body making the person immunodeficient. Immune function is typically measured by CD4 cell count. Thus, person is more likely to get infections or infection related cancers. Gradually, HIV can destroy so many of immune cells and this immunodeficiency results in susceptibility to immense range of infections, cancers, and other disease that body can’t fight off with suppressed immune system. 


• If HIV left untreated, can lead to the disease AIDS. The development of certain cancers, infections, or other severe clinical manifestations define AIDS.  However, depending on the individual it can take 2 to 15 years to develop AIDS. The human body can’t get rid of HIV completely even if treated, unlike some other viruses. So, once you have HIV, it will be lifelong. However, today someone diagnosed with HIV and treated before the disease is far advanced can live nearly as long as someone who does not have HIV.


• Key facts

• HIV continues to be a major global public health issue, having claimed more than 35 million lives so far. In 2015, 1.1 (940 000–1.3 million) million people died from HIV-related causes globally.
• There were approximately 36.7 (34.0–39.8) million people living with HIV at the end of 2015 with 2.1 (1.8–2.4) million people becoming newly infected with HIV in 2015 globally.
• Sub-Saharan Africa is the most affected region, with 25.6 (23.1–28.5) million people living with HIV in 2015. Also, sub-Saharan Africa accounts for two-thirds of the global total of new HIV infections.
• HIV infection is often diagnosed through rapid diagnostic tests (RDTs), which detect the presence or absence of HIV antibodies. Most often these tests provide same-day test results; essential for same day diagnosis and early treatment and care.
• There is no cure for HIV infection. However, effective antiretroviral (ARV) drugs can control the virus and help prevent transmission so that people with HIV, and those at substantial risk, can enjoy healthy, long, and productive lives.
• It is estimated that currently only 60% of people with HIV know their status. The remaining 40% or over 14 million people need to access HIV testing services. By mid-2016, 18.2 (16.1–19.0) million people living with HIV were receiving antiretroviral therapy (ART) globally.
• Between 2000 and 2015, new HIV infections fell by 35%, AIDS-related deaths fell by 28% with some 8 million lives saved. This achievement was the result of great efforts by national HIV programs supported by civil society and a range of development partners.
• Expanding ART to all people living with HIV and expanding prevention choices can help avert 21 million AIDS-related deaths and 28 million new infections by 2030.


TUBERCULOSIS


• Tuberculosis (TB) is an infectious disease caused by bacteria called Mycobacterium tuberculosis which most often affects the lungs, but they can also damage other parts of the body.


• Tuberculosis is curable and preventable. It spread from one person to another through tiny droplets released into the air via coughs and sneezes. If you have been exposed, you should go to your doctor for tests. You are more likely to get TB if you have a weak immune system. A person needs to inhale only a few of these germs to become infected.•One-third of the world's population is thought to be infected with latent TB, which means people have been infected by TB bacteria but not (yet) ill with the disease and cannot transmit the disease. The infected people have 10% life time risk of falling ill. However, person with compromised immune system like people living with HIV, malnutrition or diabetes, or people who use tobacco, are likely to have high risk of falling ill.


• Once rare in developed countries, tuberculosis infections began increasing in 1985, partly because of the emergence of HIV, the virus that causes AIDS. HIV weakens a person's immune system so it can't fight the TB germs. In the United States, because of stronger control programs, tuberculosis began to decrease again in 1993, but remains a concern.


• People with active tuberculosis must take several types of medications for many months to eradicate the infection and prevent development of antibiotic resistance. The symptoms of active TB (such as cough, fever, night sweats, or weight loss) may be mild for many months. This can lead to delays in seeking care, and subsequently transmitting the bacteria to others. Over a year, the active TB people can infect 10-15 other people with the close contact. Without appropriate treatment, on average 45% of HIV-negative people and nearly all HIV-positive people with TB will die. 


• Key facts

• Tuberculosis (TB) is one of the top 10 causes of death worldwide.

• In 2015, 10.4 million people fell ill with TB and 1.8 million died from the disease (including 0.4 million among people with HIV). Over 95% of TB deaths occur in low- and middle-income countries.

• Six countries account for 60% of the total, with India leading the count, followed by Indonesia, China, Nigeria, Pakistan, and South Africa.

• In 2015, an estimated 1 million children became ill with TB and 170 000 children died of TB (excluding children with HIV).

• TB is a leading killer of HIV-positive people: in 2015, 35% of HIV deaths were due to TB.

• Globally in 2015, an estimated 480 000 people developed multidrug-resistant TB (MDR-TB).

• TB incidence has fallen by an average of 1.5% per year since 2000. This needs to accelerate to a 4–5% annual decline to reach the 2020 milestones of the "End TB Strategy".

• An estimated 49 million lives were saved through TB diagnosis and treatment between 2000 and 2015.

• Ending the TB epidemic by 2030 is among the health targets of the newly adopted Sustainable Development Goals.